Title of article
Bradykinin antagonists modified with dipeptide mimetic β-turn inducers
Author/Authors
Maria C. Alcaro، نويسنده , , Valerio Vinci، نويسنده , , Anna M. D’Ursi، نويسنده , , Mario Scrima، نويسنده , , Mario Chelli، نويسنده , , Sandro Giuliani، نويسنده , , Stefania Meini، نويسنده , , Marcello Di Giacomo، نويسنده , , Lino Colombo، نويسنده , , Anna Maria Papini، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2387
To page
2390
Abstract
Bradykinin (BK) is involved in a wide variety of pathophysiological processes. Potent BK peptide antagonists can be developed introducing constrained unnatural amino acids, necessary to force the secondary structure of the molecule. In this paper, we report a structure–activity relationship study of two peptide analogues of the potent B2 antagonist HOE 140 by replacing the D-Tic-Oic dipeptide with conformationally constrained dipeptide mimetic β-turn inducers.
Keywords
Antagonist , Constrained amino acid , ?-Turn inducer , bradykinin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796786
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