Title of article
Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors
Author/Authors
Jagabandhu Das، نويسنده , , Chunjian Liu، نويسنده , , Robert V. Moquin، نويسنده , , Ming-Ji James Lin، نويسنده , , Joseph A. Furch، نويسنده , , Steven H. Spergel، نويسنده , , Kim W. McIntyre، نويسنده , , David J. Shuster، نويسنده , , Kathleen D. O’Day، نويسنده , , Becky Penhallow، نويسنده , , Chen-Yi Hung، نويسنده , , Steven B. Kanner، نويسنده , , Tai-An Lin، نويسنده , , John H. Dodd، نويسنده , , Joel C. Barrish، نويسنده , , John Wityak، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2411
To page
2415
Abstract
A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure–activity relationships (SARs), selectivity and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound 2 is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo.
Keywords
thiazoles , Selective Itk inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796790
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