Title of article
N6-Ethyl-2-alkynyl NECAs, selective human A3 adenosine receptor agonists
Author/Authors
Yong-ran Zhu، نويسنده , , Cynthia R. Frazier، نويسنده , , Joel Linden، نويسنده , , Timothy L. Macdonald، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
2416
To page
2418
Abstract
A series of N6-ethyl-2-alkynyl NECA (5′-N-ethylcarboxamidoadenosine) analogs were synthesized and their binding affinity with the four human adenosine receptors was evaluated. One of the compounds ZR1121 shows high affinity with hA3 receptor and its selectivity over hA1 receptor is 1–2 log orders greater than IB-MECA or Cl-IB-MECA, the currently employed selective A3 agonists.
Keywords
A3 adenosine agonist human NECA N6-ethyl
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796791
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