Title of article
Synthesis and antitumor activity of icogenin and its analogue
Author/Authors
Shujie Hou، نويسنده , , Peng Xu، نويسنده , , Jiong-liang Zhou، نويسنده , , Dequan Yu، نويسنده , , Pingsheng Lei، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2454
To page
2458
Abstract
Natural saponin icogenin, namely 25(S)-22-O-methyl-furost-5-en-3β,26-dio-3-O-α-l-rhamnopyranosyl-(1 → 2)-[β-d-glucopyranosyl-(1 → 3)]-β-d-glucopyranoside, and one of its analogues, 25(S)-22-O-methyl-furost-5-en-3β,26-dio-3-O-α-l-rhamnopyranosyl-(1 → 2)-[β-d-glucopyranosyl-(1 → 3)]-α-d-glucopyranoside, were first synthesized via line strategy and convergent approach, respectively. It was observed that icogenin and its analogue show potent antitumor activity in vitro.
Keywords
Saponin , Icogenin , Glycosylation , cytotoxicity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796800
Link To Document