Title of article
The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor
Author/Authors
Michael P. DeNinno، نويسنده , , Hiroko Masamune، نويسنده , , Lois K. Chenard، نويسنده , , Kenneth J. DiRico، نويسنده , , Cynthia Eller، نويسنده , , John B. Etienne، نويسنده , , Jeanene E. Tickner، نويسنده , , Scott P. Kennedy، نويسنده , , Delvin R. Knight، نويسنده , , Jimmy Kong، نويسنده , , Joseph J. Oleynek، نويسنده , , W. Ross Tracey، نويسنده , , Roger J. Hill، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
2525
To page
2527
Abstract
Using a combination of parallel and directed synthesis, the discovery of a highly potent and selective series of adenosine A3 agonists was achieved. High aqueous solubility, required for the intended parenteral route of administration, was achieved by the presence of one or two basic amine functional groups.
Keywords
adenosine , agonist , A3 , cardioprotection
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796816
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