Title of article :
The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor
Author/Authors :
Michael P. DeNinno، نويسنده , , Hiroko Masamune، نويسنده , , Lois K. Chenard، نويسنده , , Kenneth J. DiRico، نويسنده , , Cynthia Eller، نويسنده , , John B. Etienne، نويسنده , , Jeanene E. Tickner، نويسنده , , Scott P. Kennedy، نويسنده , , Delvin R. Knight، نويسنده , , Jimmy Kong، نويسنده , , Joseph J. Oleynek، نويسنده , , W. Ross Tracey، نويسنده , , Roger J. Hill، نويسنده ,
Abstract :
Using a combination of parallel and directed synthesis, the discovery of a highly potent and selective series of adenosine A3 agonists was achieved. High aqueous solubility, required for the intended parenteral route of administration, was achieved by the presence of one or two basic amine functional groups.
Keywords :
adenosine , agonist , A3 , cardioprotection
