Title of article
Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents
Author/Authors
Atul Kumar، نويسنده , , S.R. Pathak، نويسنده , , Pervez Ahmad، نويسنده , , S. Ray، نويسنده , , P. Tewari، نويسنده , , A.K. Srivastava، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2719
To page
2723
Abstract
A series of aminoalkoxy phenyl-substituted naphthalene-1-yl-methanone was synthesized and tested for its anti-hyperglycemic activity in SLM and STZ-S rat models. Some compounds (3b, 4c and 4h) of the series were showing significant anti-hyperglycemic activity in male Sprague–Dawley rats in sucrose-loaded model (SLM) as well as in streptozotocin-induced model (STZ-S). Active compounds were also evaluated for relative binding affinity against glucagon receptor.
Keywords
Naphthalen-1-yl-methanone , Anti-hyperglycemic activity , Glucagon antagonists
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796855
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