Title of article
Synthesis and SAR Studies of diarylpyrrole anticoccidial agents
Author/Authors
Xiaoxia Qian، نويسنده , , Gui-Bai Liang، نويسنده , , Dennis Feng، نويسنده , , Michael Fisher، نويسنده , , Tami Crumley، نويسنده , , Sandra Rattray، نويسنده , , Paula M. Dulski، نويسنده , , Anne Gurnett، نويسنده , , Penny Sue Leavitt، نويسنده , , Paul A. Liberator، نويسنده , , Andrew S. Misura، نويسنده , , Samantha Samaras، نويسنده , , Tamas Tamas، نويسنده , , Dennis M. Schmatz، نويسنده , , Matthew Wyvratt، نويسنده , , Tesfaye Biftu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
2817
To page
2821
Abstract
2-(4-Fluorophenyl)-3-(4-pyridinyl)-5-substituted pyrroles were prepared and evaluated as anticoccidial agents in both in vitro and in vivo assays. Among the compounds evaluated, the dimethylamine-substituted pyrrole 19a is the most potent inhibitor of Eimeria tenella PKG (cGMP-dependent protein kinase). Further SAR studies on the side chain of the 2-pyrrolidine nitrogen did not enhance in vivo anticoccidial activity.
Keywords
Anticoccidial
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796877
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