Author/Authors :
Stephen Robert Fletcher، نويسنده , , Edward McIver، نويسنده , , Stephen Lewis، نويسنده , , Frank Burkamp، نويسنده , , Clare Leech، نويسنده , , Glenn Mason، نويسنده , , Susan Boyce، نويسنده , , Denise Morrison، نويسنده , , Gillian Richards، نويسنده , , Kathy Sutton، نويسنده , , Anthony Brian Jones، نويسنده ,
Abstract :
Based on a series of diaryl amides the corresponding inverse amides have been found to be potent TRPV1 receptor antagonists. Benzimidazole and indazolone derivatives prepared retained good potency in vitro and indazolone 4a was identified as a novel TRPV1 receptor antagonist suitable for evaluating orally in animal models of analgesia.
