Author/Authors :
Jeremy R. Doncaster، نويسنده , , Laura L. Etchells، نويسنده , , Neil M. Kershaw، نويسنده , , Ryoichi Nakamura، نويسنده , , Hazel Ryan، نويسنده , , Ryo Takeuchi، نويسنده , , Kengo Sakaguchi، نويسنده , , Ali Sardarian، نويسنده , , Roger C. Whitehead، نويسنده ,
Abstract :
An array of novel analogues of the marine oxylipins, the manzamenones and plakoridines, have been prepared in divergent fashion using an approach modelled on a biogenetic theory. Many of the target compounds show potent inhibition of DNA polymerases α and β and human terminal deoxynucleotidyl transferase (TdT).
Keywords :
biomimetic synthesis , Oxylipins , natural products , DNA polymerase
