Title of article
2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists
Author/Authors
Vincent J. Colandrea، نويسنده , , Irene E. Legiec، نويسنده , , Pei Huo، نويسنده , , Lin Yan، نويسنده , , Jeffrey J. Hale، نويسنده , , Sander G. Mills، نويسنده , , James Bergstrom، نويسنده , , Deborah Card، نويسنده , , Gary Chebret، نويسنده , , Richard Hajdu، نويسنده , , Carol Ann Keohane، نويسنده , , James A. Milligan، نويسنده , , Mark J. Rosenbach، نويسنده , , Gan-Ju Shei، نويسنده , , Suzanne M. Mandala، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2905
To page
2908
Abstract
A series of 2,5-cis-disubstituted pyrrolidines were synthesized and evaluated as S1P receptor agonists. Compounds 15–21 were identified with good selectivity over S1P3 which lowered circulating lymphocytes after oral administration in mice.
Keywords
S1P receptor , Oxadiazole , Pyrrolidines , Immunosuppressants
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796894
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