Title of article
NK1 antagonists based on seven membered lactam scaffolds
Author/Authors
Jason M. Elliott، نويسنده , , Emma J. Carlson، نويسنده , , Gary G. Chicchi، نويسنده , , Olivier Dirat، نويسنده , , Maria Dominguez، نويسنده , , Ute Gerhard، نويسنده , , Richard Jelley، نويسنده , , A. Brian Jones، نويسنده , , Marc M. Kurtz، نويسنده , , Kwei-Lan Tsao، نويسنده , , Alan Wheeldon، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2929
To page
2932
Abstract
A new class of high affinity hNK1R antagonists based on seven-membered ring cores has been identified. This series, with relatively simple, compact structures, includes compounds with high affinity, good selectivity, and promising in vivo properties.
Keywords
lactam , Emesis , NK1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796899
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