Title of article
Synthesis and evaluation of a mechanism-based inhibitor of a 3-deoxy-d-arabino heptulosonate 7-phosphate synthase
Author/Authors
Scott R. Walker، نويسنده , , Emily J. Parker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
2951
To page
2954
Abstract
The first mechanism-based inhibitor of a 3-deoxy-d-arabino heptulosonate 7-phosphate (DAH7P) synthase has been synthesised in 12 steps from d-arabinose, and has been found to be a very slow binding inhibitor of Escherichia coli DAH7P synthase.
Keywords
DAHP , shikimate , DAH7P , Transition-state inhibitor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796904
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