Title of article :
Diarylacetylene piperidinyl amides as novel anxiolytics
Author/Authors :
Cheryl P. Kordik، نويسنده , , Chi Luo، نويسنده , , Maryann Gutherman، نويسنده , , Anil H. Vaidya، نويسنده , , Daniel I. Rosenthal، نويسنده , , Jeffrey J. Crooke، نويسنده , , Sandra L. McKenney، نويسنده , , Carlos R. Plata-Salamàn، نويسنده , , Allen B. Reitz، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
N-Phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (9) and related piperidine acetamide derivatives have good oral activity in the elevated plus maze, an animal model predictive of clinical efficacy for the treatment of anxiety. Modest affinity was observed for the neurokinin NK-1 and 2 receptors, which are known to be involved in the regulation of mood and emotion.
Keywords :
Neurokinin , elevated plus maze , Sonogashira coupling , Diarylacetylenes , piperidines , Anxiolytics
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
