Title of article
One-pot synthesis and SAR study of cis-2,6-dialkyl-4-chloro-tetrahydropyrans
Author/Authors
Pedro O. Miranda، نويسنده , , Leticia G. Le?n، نويسنده , , Victor S. Martin، نويسنده , , Juan I. Padron، نويسنده , , José M. Padr?n، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
3135
To page
3138
Abstract
A series of cis-2,6-dialkyl-4-chloro-tetrahydropyrans were prepared by means of an iron(III)-catalyzed process. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, SW1573, and WiDr. The results show that the presence of bulky substituents favors the Prins cyclization leading to new products with better activity profile against all cell lines tested.
Keywords
Marine drugs , Halogenated tetrahydropyrans , Solid tumors , Drug design , structure–activity relationship
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796941
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