Title of article
A pyrimidine–pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity
Author/Authors
Xuesen Fan، نويسنده , , Xinying Zhang، نويسنده , , Longhu Zhou، نويسنده , , Kathy A. Keith، نويسنده , , Earl R. Kern، نويسنده , , Paul F. Torrence، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3224
To page
3228
Abstract
Synthetic hybridization of two privileged drug scaffolds, pyrazolone on the one hand and pyrimidine nucleoside on the other, resulted in the generation of two novel 5-substituted pyrimidine nucleosides with potent in vitro antiviral activity against two representative orthopoxviruses, vaccinia virus and cowpox virus.
Keywords
Vaccinia virus , SMALLPOX , 5-Formyl-2?-deoxyuridine , Privileged drug scaffold , Cowpox virus
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796961
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