Title of article :
A pyrimidine–pyrazolone nucleoside chimera with potent in vitro anti-orthopoxvirus activity
Author/Authors :
Xuesen Fan، نويسنده , , Xinying Zhang، نويسنده , , Longhu Zhou، نويسنده , , Kathy A. Keith، نويسنده , , Earl R. Kern، نويسنده , , Paul F. Torrence، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Synthetic hybridization of two privileged drug scaffolds, pyrazolone on the one hand and pyrimidine nucleoside on the other, resulted in the generation of two novel 5-substituted pyrimidine nucleosides with potent in vitro antiviral activity against two representative orthopoxviruses, vaccinia virus and cowpox virus.
Keywords :
Vaccinia virus , SMALLPOX , 5-Formyl-2?-deoxyuridine , Privileged drug scaffold , Cowpox virus
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
