Author/Authors :
Daniele Simoni، نويسنده , , Marinella Roberti، نويسنده , , Francesco Paolo Invidiata، نويسنده , , Enrico Aiello، نويسنده , , Stefania Aiello، نويسنده , , Paolo Marchetti، نويسنده , , Riccardo Baruchello، نويسنده , , Marco Eleopra، نويسنده , , Antonietta Di Cristina، نويسنده , , Stefania Grimaudo، نويسنده , , Nicola Gebbia، نويسنده , , Lucia Crosta، نويسنده , , Francesco Dieli، نويسنده , , Manlio Tolomeo، نويسنده ,
Abstract :
Several stilbenes, related to known resveratrol, have been synthesized and tested for their anticancer effect on HL60 leukemia cell line, taking particular care of the cell cycle analysis. The most potent compound was the known (Z)-3,4′,5-trimethoxystilbene (6b) which was active as apoptotic agent at 0.24 μM. Differently from other stilbenes (including resveratrol) that induced a prevalent recruitment of cells in S phase of cell cycle, we found a peculiar behavior of 6b that caused a decrease of cells in all phases of cell cycle (G0–G1, S, and G2–M) and a proportional increase of apoptotic cells. The potent pro-apoptotic activity shown by compound 6b and its effects on cell cycle make this compound of great interest for further investigations.
