Title of article
Design and semisynthesis of novel fredericamycin A derivatives with an improved antitumor profile
Author/Authors
Ulrich Abel، نويسنده , , Werner Simon، نويسنده , , Peter Eckard، نويسنده , , Friedrich G. Hansske، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
3292
To page
3297
Abstract
We report the design, semisynthesis, and biological activity of a series of fredericamycin (1) derivatives. Within this series compound 1e combines low nanomolar cytotoxic potency in vitro, increased tumor cell line selectivity, and in vivo activity in a human xenograft model.
Keywords
Fredericamycin , antitumor , Spiro quinone , natural product , Semisynthesis
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796976
Link To Document