Title of article
Design and evaluation of new antipsoriatic antedrug candidates having 16-en-22-oxa-vitamin D3 structures
Author/Authors
KazukiShimizu، نويسنده , , Akira Kawase، نويسنده , , Tsuyoshi Haneishi، نويسنده , , Yasuharu Kato، نويسنده , , Kazutomo Kinoshita، نويسنده , , Masayuki Ohmori، نويسنده , , Yoshiyuki Furuta، نويسنده , , Takashi Emura، نويسنده , , Nobuaki Kato، نويسنده , , Tetsuya Mitsui، نويسنده , , Koji Yamaguchi، نويسنده , , Keiichi Morita، نويسنده , , Nobuo Sekiguchi، نويسنده , , Tessai Yamamoto، نويسنده , , Tomochika Matsushita، نويسنده , , Shin Shimaoka، نويسنده , , Atsuko Sugita، نويسنده , , Kazumi Morikawa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
7
From page
3323
To page
3329
Abstract
Design, synthesis, and in vitro and in vivo evaluation of a series of antipsoriatic antedrugs having 16-en-22-oxa-vitamin D3 are described. Among the seven compounds examined, two are promising: ester 5c and amide 5f, both of which exhibit greater potent antiproliferation activity with lessened calcemic activity than the presently prescribed maxacalcitol (2).
Keywords
16-En-22-oxa-24-carboalkoxide-1? , 16-En-22-oxa-24-carbamide-1? , 25-dihydroxyvitamin D3 analogs , Antedrug , Low calcemic activity , Psoriasis , 25-dihydroxyvitamin D3 analogs
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
796983
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