Author/Authors :
Sigmond G. Johnson، نويسنده , , Joseph W. Gunnet، نويسنده , , John B. Moore، نويسنده , , William Miller، نويسنده , , Pam Wines، نويسنده , , Ralph A. Rivero، نويسنده , , Don Combs، نويسنده , , Keith T. Demarest، نويسنده ,
Abstract :
A series of 1,3-disubstituted cyclohexylmethyl urea and amide derivatives were synthesized as motilin receptor antagonists. Starting from known motilin antagonists, 1a and 1b, the cyclopentene scaffold was replaced and the four recognition elements optimized to arrive at a potent novel series.
