Title of article :
Arylpiperazines with N-acylated amino acids as 5-HT1A receptor ligands
Author/Authors :
Pawe? Zajdel، نويسنده , , Gilles Subra، نويسنده , , Andrzej J. Bojarski، نويسنده , , Beata Duszy?ska، نويسنده , , Maciej Pawlowski، نويسنده , , Jean Martinez، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A library consisting of 60 arylpiperazines modified with N-acylated amino acids was prepared on BAL linker SynPhase™ Lanterns and evaluated in vitro for 5-HT1A receptor affinity. Biological screening, followed by a simple Fujita–Ban analysis, enabled the description of structure–activity relationships and allowed the selection of some potent, high-affinity ligands for in vivo pharmacological investigations.
Keywords :
succinimides , solid-phase synthesis , BAL linker , Fujita–Ban analysis , Pyroglutamates , Long-chain arylpiperazines , 5-HT1A receptor ligands
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
