Author/Authors :
Karin Briner، نويسنده , , Ivan Collado، نويسنده , , Matthew J. Fisher، نويسنده , , Cristina Garc?a-Paredes، نويسنده , , Saba Husain، نويسنده , , Steven L. Kuklish، نويسنده , , Ana I. Mateo، نويسنده , , Thomas P. O’Brien، نويسنده , , Paul L. Ornstein، نويسنده , , John Zgombick، نويسنده , , ?scar de Frutos، نويسنده ,
Abstract :
Aliphatic carbocyclic replacement of the benzyl group of compound 1 yielded compounds with high affinity for the melanocortin-4 receptor (MC4R). Compounds with a cyclohexyl group showed a consistent high affinity, while different polar groups with less basicity were good replacements for the original diethyl amines. Substitution of the polar group found in these privileged structures with an aliphatic moiety produced compounds with high affinity for MC4R.
