Title of article :
Lysine sulfonamides as novel HIV-protease inhibitors: Nε-Acyl aromatic α-amino acids
Author/Authors :
Brent R. Stranix، نويسنده , , Jean-François Lavallée، نويسنده , , Guy Sévigny، نويسنده , , Jocelyn Yelle، نويسنده , , Valérie Perron، نويسنده , , Nicholas LeBerre، نويسنده , , Dominik Herbart، نويسنده , , Jinzi J. Wu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
4
From page :
3459
To page :
3462
Abstract :
A series of lysine sulfonamide analogues bearing Nε-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses.
Keywords :
amino acids , HIV protease inhibitor , Resistant viral strains , lysine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2006
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
797011
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797011
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