Title of article
3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor
Author/Authors
Gilles C. Bignan، نويسنده , , Kathleen Battista، نويسنده , , Peter J. Connolly، نويسنده , , Michael J. Orsini، نويسنده , , Jingchun Liu، نويسنده , , Steven A. Middleton، نويسنده , , Allen B. Reitz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
3524
To page
3528
Abstract
A novel series of indoles and 1H-pyrrolo[2,3-b]pyridines having a piperidine ring at the 3-position were synthesized and found to bind with high affinity to the ORL-1 receptor. Structure–activity relationships at the piperidine nitrogen were investigated in each series. Substitution on the phenyl ring and nitrogen atom of the indole and 1H-pyrrolo[2,3-b]pyridine cores generated several selective high-affinity ligands that were agonists of the ORL-1 receptor.
Keywords
piperidine , pyridine , stress , memory , learning , ORL-1 , Nociceptin , Opioid receptor-like (ORL) , Orphanin FQ (OFQ) , N/OFQ peptide (NOP) , Indole , agonist , Anxiety
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797024
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