Author/Authors :
Lin Yan، نويسنده , , Richard Budhu، نويسنده , , Pei Huo، نويسنده , , Christopher L. Lynch، نويسنده , , Jeffrey J. Hale، نويسنده , , Sander G. Mills، نويسنده , , Richard Hajdu، نويسنده , , Carol A. Keohane، نويسنده , , Mark J. Rosenbach، نويسنده , , James A. Milligan، نويسنده , , Gan-Ju Shei، نويسنده , , Gary Chrebet، نويسنده , , James Bergstrom، نويسنده , , Deborah Card، نويسنده , , Suzanne M. Mandala، نويسنده ,
Abstract :
A series of 2-aryl(pyrrolidin-4-yl)acetic acids were synthesized and their biological activities were evaluated as agonists of S1P receptors. These analogs were able to induce lowering of lymphocyte counts in the peripheral blood of mice and were found to have good overall pharmacokinetic properties in rat.
Keywords :
Immunosuppressants , S1P agonists , (Pyrrolidin-4-yl)acetic acids , Peripheral lymphocyte lowering
