Title of article :
3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors
Author/Authors :
Christopher M. McBride، نويسنده , , Paul A. Renhowe، نويسنده , , Thomas G. Gesner، نويسنده , , Johanna M. Jansen، نويسنده , , Julie Lin، نويسنده , , Sylvia Ma، نويسنده , , Yasheen Zhou، نويسنده , , Cynthia M. Shafer، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
The 3-benzimidazol-2-yl-1H-indazole scaffold was developed as an alternate scaffold for our receptor tyrosine kinase (RTK) inhibitor program. In exploring the SAR of this series, it was discovered that a subset of these compounds potently inhibit the enzyme c-ABL. The SAR of these compounds is described.
Keywords :
Indazole , Benzimidazole , Protein tyrosine kinase , c-Abl , Chronic myelogenous leukemia (CML)
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
