Author/Authors :
Yasuko Takahashi، نويسنده , , Haruhiko Fuwa، نويسنده , , Akane Kaneko، نويسنده , , Makoto Sasaki، نويسنده , , Satoshi Yokoshima، نويسنده , , Hifumi Koizumi، نويسنده , , Tohru Takebe، نويسنده , , Toshiyuki Kan، نويسنده , , Takeshi Iwatsubo، نويسنده , , Taisuke Tomita، نويسنده , , Hideaki Natsugari، نويسنده , , Tohru Fukuyama، نويسنده ,
Abstract :
Screening of our in-house compound library comprised of intermediates of natural product synthesis projects resulted in discovering two novel γ-secretase inhibitors, which coincidently had similar moieties, that is, cyclohexenone and two aryl groups arranged on the core six-membered ring. Structure–activity relationship studies of these compounds were also developed.
Keywords :
?-Secretase , inhibitor , Structure–activity relationships , Cyclohexenone
