Title of article :
Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring
Author/Authors :
Todd W. Rockway، نويسنده , , Rong Zhang، نويسنده , , Dachun Liu، نويسنده , , David A. Betebenner، نويسنده , , Keith F. McDaniel، نويسنده , , John K. Pratt، نويسنده , , David Beno، نويسنده , , Debra Montgomery، نويسنده , , Wen W. Jiang، نويسنده , , Sherie Masse، نويسنده , , Warren M. Kati، نويسنده , , Tim Middleton، نويسنده , , Akhteruzzaman Molla، نويسنده , , Clarence J. Maring، نويسنده , , Dale J. Kempf، نويسنده ,
Abstract :
A series of non-nucleoside HCV NS5B polymerase inhibitors based on the N-1-benzyl or N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine core substituted in the D-ring aromatic moiety have been prepared and evaluated. Aromatic substituents extending from position 7 of the D-ring exhibited excellent potency against both genotypes 1a and 1b.
Keywords :
N-1-Benzyl or N-1-3-methylbutyl-4-hydroxy-1 , HCV NS5B polymerase , 8-naphthyridon-3-yl benzothiadiazine
