Title of article :
3-Substituted gem-cyclohexane sulfone based γ-secretase inhibitors for Alzheimer’s disease: Conformational analysis and biological activity
Author/Authors :
Richard A. Jelley، نويسنده , , Jason Elliott، نويسنده , , Karl R. Gibson، نويسنده , , Timothy Harrison، نويسنده , , Dirk Beher، نويسنده , , Earl E. Clarke، نويسنده , , Huw D. Lewis، نويسنده , , Mark Shearman، نويسنده , , Jonathan D.J. Wrigley، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Previously, chemistry effort on the gem-cyclohexane series of γ-secretase inhibitors has focused on the 4-position of the cyclohexane ring. Recently chemistry has been directed towards the 3-position and substitution here has also provided compounds with high γ-secretase activity.
Keywords :
gem-Cyclohexane , Sulfone , ?-Secretase inhibitors , Alzheimer’s disease , Conformational analysis , biological activity
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
