Title of article
Azadideoxyadenosine: Synthesis, enzymology, and anti-HIV activity
Author/Authors
Abdumalik A. Nishonov، نويسنده , , Xiaohui Ma، نويسنده , , Vasu Nair، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
4099
To page
4101
Abstract
Synthesis of an azanucleoside, a new analogue of dideoxyadenosine, is described. This compound is only slowly deaminated by mammalian adenosine deaminase and it is a substrate for adenosine kinase. It exhibits in vitro anti-HIV activity.
Keywords
Azanucleoside , Anti-HIV activity , adenosine deaminase , synthesis , kinase phosphorylation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797143
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