Title of article :
Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents
Author/Authors :
Byul Nae Yoo، نويسنده , , Hea Ok Kim، نويسنده , , Hyung Ryong Moon، نويسنده , , Su Kyung Seol، نويسنده , , Sung Key Jang، نويسنده , , Kang Man Lee، نويسنده , , Lak Shin Jeong، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
On the basis of potent anti-HCV activity of 2′-C-methyladenosine, novel 2′-C-hydroxymethyladenosine analogues 2a–c were synthesized from d-ribose in order to lead to favorable interaction with HCV polymerase. Among compounds tested, adenosine derivative 2a exhibited potent anti-HCV activity, indicating that the hydroxyl group of 2′-C-hydroxymethyl substituent led to favorable interaction with HCV polymerase.
Keywords :
Anti-HCV agent , 2?-C-Hydroxymethyladenosine , hepatitis C virus , RNA dependent RNA polymerase
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
