Title of article
Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists
Author/Authors
Brian Dyck، نويسنده , , Liren Zhao، نويسنده , , Junko Tamiya، نويسنده , , Joseph Pontillo، نويسنده , , Sarah Hudson، نويسنده , , Brett Ching، نويسنده , , Christopher E. Heise، نويسنده , , Jenny Wen، نويسنده , , Christi Norton، نويسنده , , Ajay Madan، نويسنده , , David Schwarz، نويسنده , , Warren Wade، نويسنده , , Val S. Goodfellow، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
6
From page
4237
To page
4242
Abstract
A series of substituted chromones were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor 1. Compounds with subnanomolar binding affinity and 66% oral bioavailability in rats were discovered.
Keywords
GPCR , MCH , obesity , Anorectic , Anxiety , depression
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797169
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