Author/Authors :
Martha De La Rosa، نويسنده , , Hong Woo Kim، نويسنده , , Esmir Gunic، نويسنده , , Cheryl Jenket، نويسنده , , Uyen Boyle، نويسنده , , Yung-hyo Koh، نويسنده , , Ilia Korboukh، نويسنده , , Matthew Allan، نويسنده , , Weijian Zhang، نويسنده , , Huanming Chen، نويسنده , , Wen Xu، نويسنده , , Shahul Nilar، نويسنده , , Nanhua Yao، نويسنده , , Robert Hamatake، نويسنده , , Stanley A. Lang Jr.، نويسنده , , Zhi Hong، نويسنده , , Zhijun Zhang، نويسنده , , Jean-Luc Girardet، نويسنده ,
Abstract :
A new series of 1,2,4-triazoles was synthesized and tested against several NNRTI-resistant HIV-1 isolates. Several of these compounds exhibited potent antiviral activities against efavirenz- and nevirapine-resistant viruses, containing K103N and/or Y181C mutations or Y188L mutation. Triazoles were first synthesized from commercially available substituted phenylthiosemicarbazides, then from isothiocyanates, and later by condensing the desired substituted anilines with thiosemicarbazones.
Keywords :
Y188L , antiviral , HIV-1 , triazole , NNRTI , Y181C , K103N
