Title of article
Development of first photoresponsive prodrug of paclitaxel
Author/Authors
Mariusz Skwarczynski، نويسنده , , Mayo Noguchi، نويسنده , , Shun Hirota، نويسنده , , Youhei Sohma، نويسنده , , Tooru Kimura، نويسنده , , Yoshio Hayashi، نويسنده , , Yoshiaki Kiso، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
4492
To page
4496
Abstract
A prodrug of paclitaxel which has a coumarin derivative conjugated to the amino acid moiety of isotaxel (O-acyl isoform of paclitaxel) has been synthesized. The prodrug was selectively converted to isotaxel by visible light irradiation (430 nm) with the cleavage of coumarin. Finally, paclitaxel was released by subsequent spontaneous O–N intramolecular acyl migration.
Keywords
taxol , Photoresponsive , Tumor targeting prodrug , O–N intramolecular acyl migration , coumarin , Visible light irradiation
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797216
Link To Document