Title of article :
Hydrazides of clozapine: A new class of D1 dopamine receptor subtype selective antagonists
Author/Authors :
T.K. Sasikumar، نويسنده , , D.A. Burnett، نويسنده , , H. Zhang، نويسنده , , A. Smith-Torhan، نويسنده , , Amani A. Fawzi، نويسنده , , J.E. Lachowicz، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Acylated and aroylated hydrazinoclozapines are highly potent dopamine D1 antagonists that show remarkable selectivity over other dopamine receptors. The most potent compound in this series is the 2,6-dimethoxybenzhydrazide 33 with a D1Ki of 1.6 nM and 212-fold selectivity over D2 receptor.
Keywords :
Hydrazinoclozapine , Dopamine D1 , Clozapine
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
