Author/Authors :
David A. Price، نويسنده , , Duncan Armour، نويسنده , , Marcel de Groot، نويسنده , , Derek Leishman، نويسنده , , Carolyn Napier، نويسنده , , Manos Perros، نويسنده , , Blanda L. Stammen، نويسنده , , Anthony Wood، نويسنده ,
Abstract :
The discovery of maraviroc 17 is described with particular reference to the generation of high selectivity over affinity for the HERG potassium channel. This was achieved through the use of a high throughput binding assay for the HERG channel that is known to show an excellent correlation with functional effects.
Keywords :
Tropanes , ion channel , HERG , Maraviroc , triazoles
