Title of article
Benzimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists
Author/Authors
Istv?n Borza، نويسنده , , S?ndor Kolok، نويسنده , , Anik? Gere، نويسنده , , J?zsef Nagy، نويسنده , , Laszlo Fodor، نويسنده , , Kornél Galg?czy، نويسنده , , J?zsef Fetter، نويسنده , , Ferenc Bertha، نويسنده , , Béla ?gai، نويسنده , , Csilla Horv?th، نويسنده , , S?ndor Farkas، نويسنده , , Gy?rgy Dom?ny، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
4638
To page
4640
Abstract
A novel series of benzimidazole-2-carboxamide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of some structural elements, like H-bond donor groups placed on the benzimidazole skeleton and the substitution pattern of the piperidine ring, on the biological activity was studied. Compound 6a showed excellent analgetic activity in the mouse formalin test following po administration.
Keywords
Benzimidazole , NR2B , NMDA
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797247
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