Author/Authors :
Istv?n Borza، نويسنده , , S?ndor Kolok، نويسنده , , Anik? Gere، نويسنده , , J?zsef Nagy، نويسنده , , Laszlo Fodor، نويسنده , , Kornél Galg?czy، نويسنده , , J?zsef Fetter، نويسنده , , Ferenc Bertha، نويسنده , , Béla ?gai، نويسنده , , Csilla Horv?th، نويسنده , , S?ndor Farkas، نويسنده , , Gy?rgy Dom?ny، نويسنده ,
Abstract :
A novel series of benzimidazole-2-carboxamide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of some structural elements, like H-bond donor groups placed on the benzimidazole skeleton and the substitution pattern of the piperidine ring, on the biological activity was studied. Compound 6a showed excellent analgetic activity in the mouse formalin test following po administration.
