Author/Authors :
Xiaodong Lin، نويسنده , , Alice C. Rico، نويسنده , , Daniel T. Chu، نويسنده , , Georgia L. Carroll، نويسنده , , Lynn Barker، نويسنده , , Ribhi Shawar، نويسنده , , Manoj C. Desai، نويسنده , , Jacob J. Plattner، نويسنده ,
Abstract :
Synthesis of C12 des-methyl ketolide is developed featuring an intramolecular epoxide formation/elimination process to establish the C12 stereocenter. These ketolides are potent against several key respiratory pathogens, including erythromycin resistant erm- and mef-containing strains of Streptococcus pneumoniae.
