Title of article
Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines
Author/Authors
Anna Soroka، نويسنده , , Pieter Van der Veken، نويسنده , , Ingrid De Meester، نويسنده , , Anne-Marie Lambeir، نويسنده , , Marie-Berthe Maes، نويسنده , , Simon Scharpe، نويسنده , , Achiel Haemers، نويسنده , , Koen Augustyns، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
3
From page
4777
To page
4779
Abstract
In this paper, we report the synthesis of diastereomerically pure N-(4-substituted-2,4-diaminobutanoyl)piperidines. These compounds were prepared to investigate the influence of the 4-substitution on the dipeptidyl peptidase II (DPP II) activity and selectivity of the parent N-(2,4-diaminobutanoyl)piperidine. The (4S)-methyl compound showed subnanomolar inhibition, comparable with the parent compound. The (4R)-methyl group or bigger substituents decreased the activity.
Keywords
4-Diaminoalkanoylpiperidines , Dipeptidyl peptidases , DPP II , 2 , inhibitors
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797275
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