Title of article :
Synthesis and anti-tumor evaluation of new trisulfide derivatives
Author/Authors :
Haoyun An، نويسنده , , Jenny Zhu، نويسنده , , Xiaobo Wang، نويسنده , , Xiao Xu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
New bis-aromatic and heterocyclic trisulfide derivatives 5, 7–10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4) to evaluate their anti-tumor activities. Five compounds 5–7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system.
Keywords :
Anti-tumor activity , Trisulfide , synthesis , SAR
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters