• Title of article

    Discovery of a novel series of inhibitors of human cytomegalovirus primase

  • Author/Authors

    T.D. Cushing، نويسنده , , J. Adrian، نويسنده , , X. Chen، نويسنده , , H. DiMaio، نويسنده , , B. Doughan، نويسنده , , J. Flygare، نويسنده , , L. Liang، نويسنده , , V. Mayorga، نويسنده , , S. Miao، نويسنده , , H. Mellon، نويسنده , , M.G. Peterson، نويسنده , , J.P. Powers، نويسنده , , F. Spector، نويسنده , , C. Stein، نويسنده , , M. Wright، نويسنده , , D. Xu، نويسنده , , Q. Ye، نويسنده , , J. Jaen، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2006
  • Pages
    5
  • From page
    4879
  • To page
    4883
  • Abstract
    Infection by human cytomegalovirus (hCMV) remains a potent threat to susceptible people throughout the world. We have discovered a series of imidazolyl-pyrimidine compounds, which were found to be irreversible inhibitors of the hCMV UL70 primase based on results from radiolabeling and SAR studies. Two promising analogs are described that rival ganciclovir and cidofovir in antiviral potency and possess improved cytotoxicity profiles.
  • Keywords
    Radiolabeling , Tritiation , CMV , Cytomegalovirus , Ganciclovir , Imidazolyl-pyrimidine , Cidofovir , Irreversible inhibitor , UL70 primase
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2006
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    797298

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797298