Title of article
Pharmacophore-based virtual screening: The discovery of novel methionyl-tRNA synthetase inhibitors
Author/Authors
Su Yeon Kim ، نويسنده , , Yeon Sook Lee، نويسنده , , Taehee Kang، نويسنده , , Sunghoon Kim، نويسنده , , Jeewoo Lee، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
10
From page
4898
To page
4907
Abstract
We have performed virtual screening of a chemical database of 508,143 commercially available chemicals to search for new methionyl-tRNA synthetase (MetRS) inhibitors. In this study, potent lead compounds with a novel skeleton, including compound 27 with IC50 = 237 nM, were successfully identified as Escherichia coli MetRS inhibitors.
Keywords
Methionyl-tRNA synthetase inhibitors , Virtual ligand screening
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797302
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