مرکز منطقه ای اطلاع رساني علوم و فناوري - Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand

Title of article :

Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand

Author/Authors :

Scott E. Wolkenberg، نويسنده , , Zhijian Zhao، نويسنده , , Marianna Kapitskaya، نويسنده , , Andrea L. Webber، نويسنده , , Konstantin Petrukhin، نويسنده , , Yui Sing Tang، نويسنده , , Dennis C. Dean، نويسنده , , George D. Hartman، نويسنده , , Craig W. Lindsley، نويسنده ,

Issue Information :

روزنامه با شماره پیاپی سال 2006

Pages :

From page :

5001

To page :

5004

Abstract :

Agonists of NR2E3 (PNR, RNR) have been identified and optimized to EC50 < 200 nM. A tritiated analogue of one agonist was prepared to aid in the development of a binding assay.

Keywords :

AMD , Nuclear receptor , NR2E3 , PNR , RNR , Age-Related Macular Degeneration , Ophthalmics

Journal title :

Bioorganic & Medicinal Chemistry Letters

Serial Year :

2006

Journal title :

Bioorganic & Medicinal Chemistry Letters

Record number :

797317

Link To Document :

https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=797317