Title of article
Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities
Author/Authors
Jian Li، نويسنده , , Mingyue Zheng، نويسنده , , Wei Tang، نويسنده , , Pei-Lan Ding، نويسنده , , WeiLiang Zhu، نويسنده , , Tianxian Li، نويسنده , , Jian-Ping Zuo، نويسنده , , Hong Liu، نويسنده , , Hualiang Jiang and Helmut Grubmüller، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
5009
To page
5013
Abstract
Sixteen novel 4-triazole-modified zanamivir (1) analogues were synthesized using the click reactions, and their inhibitory activities against avian influenza virus (AIV, H5N1) were determined. Compound 3b exerts promising inhibitory activity with EC50 of 6.4 μM, which is very close to that of zanamivir (EC50 = 2.8 μM). Molecular modeling provided the information about the binding model between inhibitors and neuraminidase, which are in good agreement with inhibitory activities.
Keywords
Zanamivir analogues , Avian influenza virus , click chemistry , Molecular modeling
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797319
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