Title of article
Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers
Author/Authors
Jae Yeol Lee، نويسنده , , Seong Jun Park، نويسنده , , Sung-Jun Park، نويسنده , , Min Joo Lee، نويسنده , , Hyewhon Rhim، نويسنده , , Seon Hee Seo، نويسنده , , Ki-Sun Kim، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5014
To page
5017
Abstract
This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.
Keywords
Cancer cell , growth inhibition , T-type calcium channel blockers , cisplatin
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797320
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