Title of article
Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs
Author/Authors
Wei Zeng، نويسنده , , T. Eric Ballard، نويسنده , , Alexander G. Tkachenko، نويسنده , , Virginia A. Burns، نويسنده , , Daniel L. Feldheim، نويسنده , , Christian Melander، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
5148
To page
5151
Abstract
Under appropriate electronic modulation, simple diazofluorene analogs recapitulate the DNA cleavage activity of kinamycin D under thiol-based reducing conditions. Achieving DNA cleavage under these reducing conditions is key to anticancer activity, as the most active compound, 1-methoxydiazofluorene, inhibits the proliferation of HeLa cells.
Keywords
Lomaiviticins , DNA cleavage , Diazofluorenes , Kinamycins , antiproliferative activity
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797347
Link To Document