Title of article
4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists
Author/Authors
Jinlong Jiang، نويسنده , , Peter Lin، نويسنده , , Myle Hoang، نويسنده , , Lehua Chang، نويسنده , , Carina Tan، نويسنده , , Scott Feighner، نويسنده , , Oksana C. Palyha، نويسنده , , Donna L. Hreniuk، نويسنده , , Jie Pan، نويسنده , , Andreas W. Sailer، نويسنده , , Nancy R. Morin، نويسنده , , Douglas J. MacNeil، نويسنده , , Andrew D. Howard، نويسنده , , Lex H.T. Van der Ploeg، نويسنده , , Mark T. Goulet، نويسنده , , Robert J. DeVita، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
5275
To page
5279
Abstract
Structure–activity relationships of a 4-aminoquinoline MCH1R antagonist lead series were explored by synthesis of analogs with modifications at the 2-, 4-, and 6-positions of the original HTS hit. Improvements to the original screening lead included lipophilic groups at the 2-position and biphenyl, cyclohexyl phenyl, and hydrocinnamyl carboxamides at the 6-position. Modifications of the 4-amino group were not well tolerated.
Keywords
obesity , Antagonist , Anxiety , Quinoline , Melanin-concentrating hormone , MCH , depression
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797369
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