Title of article :
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: A new class of pestivirus inhibitors
Author/Authors :
Gerhard Puerstinger، نويسنده , , Jan Paeshuyse، نويسنده , , Piet Herdewijn، نويسنده , , Jef Rozenski، نويسنده , , Erik De Clercq، نويسنده , , Johan Neyts، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A novel class of inhibitors of pestiviruses (5-substituted 2-phenyl-5H-imidazo[4,5-c]pyridines) is described. Modification of the substituent in position 5 resulted in analogues with high activity (EC50 < 100 nM) and selectivity (SI > 1000) against the pestivirus BVDV (bovine viral diarrhea virus).
Keywords :
5-c]pyridines , Pestivirus inhibitors , BVDV , HCV , antiviral
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
