Author/Authors :
Octerloney McDonald، نويسنده , , Karen Lackey، نويسنده , , Ronda Davis-Ward، نويسنده , , Edgar Wood، نويسنده , , Vicente Samano، نويسنده , , Patrick Maloney، نويسنده , , Felix Deanda، نويسنده , , Robert Hunter، نويسنده ,
Abstract :
The synthesis of several novel aza-stilbene derivatives was carried out. The compounds were tested for their c-RAF enzyme inhibition. Compound 27 possesses significant potency against c-RAF and demonstrates selectivity over other protein kinases. A hypothesis for the binding mode, activity, and selectivity is proposed.
