• Title of article

    Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains

  • Author/Authors

    Sandra Gemma، نويسنده , , Gagan Kukreja، نويسنده , , Caterina Fattorusso، نويسنده , , Marco Persico، نويسنده , , Maria P. Romano، نويسنده , , Maria Altarelli، نويسنده , , Luisa Savini، نويسنده , , Giuseppe Campiani، نويسنده , , Ernesto Fattorusso، نويسنده , , Nicoletta Basilico، نويسنده , , Donatella Taramelli، نويسنده , , Vanessa Yardley، نويسنده , , Stefania Butini، نويسنده ,

  • Issue Information
    روزنامه با شماره پیاپی سال 2006
  • Pages
    5
  • From page
    5384
  • To page
    5388
  • Abstract
    A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.
  • Keywords
    malaria , hydrazones , Hemozoin
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Serial Year
    2006
  • Journal title
    Bioorganic & Medicinal Chemistry Letters
  • Record number

    797392