Author/Authors :
Sandra Gemma، نويسنده , , Gagan Kukreja، نويسنده , , Caterina Fattorusso، نويسنده , , Marco Persico، نويسنده , , Maria P. Romano، نويسنده , , Maria Altarelli، نويسنده , , Luisa Savini، نويسنده , , Giuseppe Campiani، نويسنده , , Ernesto Fattorusso، نويسنده , , Nicoletta Basilico، نويسنده , , Donatella Taramelli، نويسنده , , Vanessa Yardley، نويسنده , , Stefania Butini، نويسنده ,
Abstract :
A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.
