Author/Authors :
Sang-Jip Nam، نويسنده , , Hyunsil Ko، نويسنده , , Mihee Shin، نويسنده , , Jungyeob Ham، نويسنده , , Jungwook Chin، نويسنده , , Youngshin Kim، نويسنده , , Heeyoung Kim، نويسنده , , Kyoungjin Shin، نويسنده , , Hyukjae Choi، نويسنده , , Heonjoong Kang، نويسنده ,
Abstract :
Three novel (1–3) and two known (4–5) scalarane sesterterpenes were isolated from a marine sponge of the genus Spongia. The isolated compounds showed potent inhibition of transactivation for the nuclear hormone receptor, FXR (farnesoid X-activated receptor), which is a promising drug target to treat hypercholesterolemia in humans.
Keywords :
Marine sponge , Farnesoid X-activated receptor , Scalarane sesterterpene , Guggulsterone , Hypercholesterolemia
